Carbon monoxide as a biomarker and therapeutic agent

A - Human Necessities – 61 – K

Patent

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A61K 33/00 (2006.01)

Patent

CA 2484770

The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including primary pulmonary hypertension, secondary pulmonary hypertension, cancers, including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, Alzheimer's disease, peripheral vascular disease and pulmonary vascular thrombotic diseases such as pulmonary embolism. CO may be used to provide anti- inflammatory relief in patients suffering from oxidative stress and other conditions especially including sepsis and septic shock. In addition, carbon monoxide may be used as a biomarker or therapeutic agent for reducing respiratory distress in lung transplant patients and to reduce or inhibit oxidative stress and inflammation in transplant patients.

La présente invention concerne l'utilisation de monoxyde de carbone (CO) en tant que biomarqueur et qu'agent thérapeutique des maladies du coeur, du poumon, du foie, de la rate, du cerveau, de la peau et du rein ainsi que d'autres états et maladies pathologiques comprenant, par exemple, l'asthme, l'emphysème, la bronchite, le syndrome de détresse respiratoire de l'adulte, la sepsie, la mucoviscidose, la pneumonie, les maladies pulmonaires intersticielles, les maladies pulmonaires idiopathiques, d'autres maladies pulmonaires comprenant l'hypertension pulmonaire primaire, l'hypertension pulmonaire secondaire, les cancers, notamment le cancer du poumon, du larynx et de la gorge, l'arthrite, la cicatrisation de blessure, la maladie de Parkinson, la maladie d'Alzheimer, la maladie vasculaire périphérique et les maladies thrombotiques vasculaires pulmonaires telles que l'embolie pulmonaire. Le CO peut être utilisé pour assurer un soulagement anti-inflammatoire chez des patients souffrant de stress oxydatif et d'autres états pathologiques comprenant notamment la sepsie et le choc infectieux. De plus, le monoxyde de carbone peut être utilisé en tant que biomarqueur ou qu'agent thérapeutique pour réduire la détresse respiratoire chez des patients ayant subi une greffe pulmonaire et pour réduire ou inhiber le stress oxydatif et l'inflammation chez des greffés.

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