Carbonate prodrugs and methods of using the same

Details Carbonate prodrugs and methods of using the same Carbonate prodrugs and methods of using the same

C - Chemistry, Metallurgy

07

F

C07F 9/09 (2006.01) A61K 31/661 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2724881

The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.

L'invention porte sur des promédicaments carbonatés comprenant un fragment d'anhydride phosphorique carbonique lié au groupe hydroxyle ou carboxyle d'un fragment de médicament parent. Lesdits promédicaments peuvent avoir des propriétés physicochimiques améliorées par rapport aux médicaments parents. L'invention porte également sur des méthodes de traitement de maladies ou états répondant au médicament parent et utilisant lesdits promédicaments carbonatés, ainsi que sur des doses unitaires et des trousses.

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