Carbonyl compounds as inhibitors of histone deacetylase for...

Details Carbonyl compounds as inhibitors of histone deacetylase for... Carbonyl compounds as inhibitors of histone deacetylase for...

C - Chemistry, Metallurgy

07

C

C07C 331/04 (2006.01) A61K 31/12 (2006.01) A61K 31/167 (2006.01) A61K 31/26 (2006.01) A61K 31/357 (2006.01) A61K 31/426 (2006.01) C07C 323/22 (2006.01) C07C 323/29 (2006.01) C07C 323/67 (2006.01) C07C 331/10 (2006.01) C07C 331/12 (2006.01) C07D 277/16 (2006.01) C07D 277/36 (2006.01) C07D 277/52 (2006.01) C07D 319/18 (2006.01)

Patent

CA 2528003

Disclosed herein are carbonyl compounds of Formula (I), (II) or (III), and others as described herein. Also disclosed are methods of treating disease, such as cancer, neurological disorders, including polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, autoimmune diseases and cardiovascular conditions, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Cette invention concerne des composés carbonyle représentés par la formule (I), (II) ou (III), ainsi que d'autres composés décrits dans les pièces descriptives de la demande. Cette invention concerne également des procédés de traitement de maladies, telles que le cancer, les affections neurologiques, notamment les troubles de répétition de la polyglutamine, les anémies, les thalassémies, les états inflammatoires, les maladies auto-immunes et les états cardio-vasculaires, au moyen de ces composés. Cette invention concerne en outre des procédés pour moduler l'activité de l'histone désacétylase (HDAC).

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