Carbonylamino-derivatives as novel inhibitors of histone...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2476067

This invention comprises the novel compounds of formula (I)wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

L'invention concerne des nouveaux composés de formule générale (I) dans laquelle n, m, t, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, L, Q, X, Y et a) ont la signification indiquée dans la description, qui présentent une activité enzymatique inhibant l'histone déacetylase. L'invention concerne également leur préparation, des compositions les contenant ainsi que leur utilisation en tant que médicament.

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