Carboranylporphyrins and uses thereof

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 5/02 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 35/00 (2006.01) C07D 487/22 (2006.01)

Patent

CA 2671849

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

La présente invention porte sur des composés boronés de faible toxicité et sur leurs procédés pour leur utilisation dans le traitement, la visualisation et le diagnostic des tumeurs. Plus spécifiquement, la présente invention porte sur des composés de porphyrine à teneur en carborane de faible toxicité avec des groupes halogénure, amine ou nitro et des procédés pour leur utilisation en particulier dans la thérapie de capture des neutrons de bore (BNCT), une thérapie par radiation de rayons X (XRT) et une thérapie photodynamique (PDT) pour le traitement de tumeurs dans le cerveau, la tête et le cou et le tissu environnant. L'invention porte également sur l'utilisation de ces composés de porphyrine à teneur en carborane dans des procédés d'imagerie et/ou de diagnostic de tumeurs tels que IRM, SPECT ou PET.

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