C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/226, 260/277
C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 215/227 (2006.01) C07D 405/14 (2006.01)
Patent
CA 1252469
ABSTRACT OF THE DISCLOSURE Novel carbostyril derivative and its salt, having excellent platelates aggregation inhibitory effect, calcium antagonism, hypotensive effect and phosphodiesterase inhibitory effect, thus the carbostyril derivative of the present invention is useful as prophylactic or treating agent for thrombosis, circulation improving agent for coro- nary blood flow such as coronary vasodilator, hypotensive agent and phosphodiesterase inhibitor. Furthermore, the carbostyril derivative of the present invention is featured very weak in the hear rate increasing activity and also in the cardiac muscle contraction increasing activity, the carbostyril derivative is useful agent for curing and treating the heart diseases such as cardiac angina and myocardial infarction caused by hypercoagulability of the platelets.
435962
Nagami Kazuyoshi
Nakagawa Kazuyuki
Tamada Shigeharu
Tanaka Tatsuyoshi
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Co. Ltd.
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