Carbostyril derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 215/22 (2006.01) C07D 213/38 (2006.01) C07D 215/227 (2006.01) C07D 309/04 (2006.01) C07D 401/00 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1159068

ABSTRACT OF THE DISCLOSURE Novel carbostyril derivatives are provided having excellent blood platelet aggregation inhibitory effect, phosphodiesterase inhibitory effect, myocardium contraction increasing effect, anti-ulcer effect, antiinflammatory effect, hypotensive effect, cerebral blood flow increasing effect, blood plate- let clot dissociation effect and the like, These derivatives are useful as prophylaxis and treating agent for thrombosis and embolism, such as cerebral apoplexy, cerebral infarction, myocardial infarction; cerebral blood flow im- prover, anti-inflammatory agent, hypotensive agent or the like. The novel carbostyril derivatives of the invention are represented by the general formula (1): Image (I) wherein a typical value for R1 is hydrogen, for R2 is hydrogen, for R3 is a lower alkyl group, for R4 is a heterocyclic ring residue and for A is a lower alkene group.

353541

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