A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/19 (2006.01) A61K 31/519 (2006.01)
Patent
CA 2526562
The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-serotonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamazapine, oxcarbamazapine, zonisamide, lamotrigine , topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.
L'invention concerne une composition pharmaceutique comprenant un dérivé de carbostyrile qui est un stabilisateur du système dopamine-sérotonine dans un excipient pharmaceutiquement acceptable. Le dérivé de carbostyrile peut être un aripiprazole ou un métabolite de celui-ci. Le psychorégulateur peut comporter notamment lithium, acide valproïque, divalproex de sodium, carbamazapine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentine, lévétiracétame ou clonazépame. Ces compositions sont utilisées dans le traitement de patients souffrant de troubles de l'humeur, en particulier du trouble bipolaire avec ou sans caractéristiques psychotiques, épisodes maniaques ou mixtes. L'invention concerne en outre des procédés d'administration séparée d'un dérivé de carbostyrile et d'un psychorégulateur à un patient souffrant de trouble de l'humeur.
Hirose Tsuyoshi
Iwamoto Taro
Kikuchi Tetsuro
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Co. Ltd.
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