Carbostyril derivatives and serotonin reuptake inhibitors...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/496 (2006.01) A61K 31/135 (2006.01) A61K 31/15 (2006.01) A61K 31/165 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/4525 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2511619

The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof, which is a dopamine-serotonin system stabilizer. The serotonin reuptake inhibitor may be fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline or escitalopram. The pharmaceutical composition of the present invention is useful for treating patients with mood disorders, particularly depression or major depressive disorder.

La présente invention se rapporte à une composition pharmaceutique comportant (1) un dérivé de carbostyrile et (2) un inhibiteur de réabsorption de sérotonine dans un excipient pharmaceutiquement acceptable. Le dérivé de carbostyrile peut être aripiprazole ou un métabolite de ce composé, qui est un stabilisateur du système dopamine-sérotonine. L'inhibiteur de réabsorption de la sérotonine peut être fluoxétine, duloxétine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxétine, sertraline ou escitalopram. La composition pharmaceutique de la présente invention est utile pour traiter des patients présentant des troubles de l'humeur, en particulier une dépression ou un trouble dépressif majeur.

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