Carbostyril derivatives and their use

Details Carbostyril derivatives and their use Carbostyril derivatives and their use

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/137 (2006.01) A61K 31/155 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/55 (2006.01) C07D 215/227 (2006.01) C07D 215/26 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01)

Patent

CA 2067475

Disclosed are carbostyril derivatives of the general formula (see above formula) wherein R1a is a halogen or a lower alkoxy, lower alkyl, lower alkenyloxy, amino, lower alkanoylamino or lower alkylthio group; R2 is a phenyl group which optionally may have one or two substituents each independently selected from the group consisting of halogen, lower alkoxy, lower alkyl, nitro, amino, lower alkanoylamino, hydroxyl, cyano, phenyl-lower alkoxy and halo-lower alkyl; A is a lower alkylene group; and the carbon-carbon bond between the positions 3 and 4 of the carbostyril skeleton is a single bond or a double bond; and salts thereof, and pharmaceutical compositions containing the same, for use as a disturbance-of- consciousness improving agent, central nervous system stimulent or sigma receptor agonist.

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