Carboxamide compounds for the treatment of metabolic disorders

Details Carboxamide compounds for the treatment of metabolic disorders Carboxamide compounds for the treatment of metabolic disorders

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 211/58 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2722139

Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

La présente invention concerne des composés de carboxamide, ainsi que des compositions pharmaceutiques et des procédés dutilisation. Un mode de réalisation concerne un composé ayant la structure dans laquelle R1, R2, R3, R4, D, J, Z, T, p, q, w et x sont comme décrit dans la description. Dans certains modes de réalisation, un composé décrit dans la description active la voie AMPK, et peut être utilisé pour traiter des troubles et pathologies liés au métabolisme.

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