C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/179, 260/263
C07F 9/40 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/572 (2006.01) C07F 9/58 (2006.01) C07F 9/59 (2006.01) C07F 9/60 (2006.01) C07F 9/62 (2006.01) C07F 9/6506 (2006.01) C07F 9/6509 (2006.01) C07F 9/653 (2006.01) C07F 9/6533 (2006.01) C07F 9/6547 (2006.01)
Patent
CA 1339370
Novel carboxamide compounds represented by the general formula (I) (see fig. I) (wherein R1 and R2 are each (i) H, (ii) alkyl, (iii) phenyl optionally having 1 to 34 substituents such as halogen, carbamoyl, alkanoyl, benzoyl, dialkylamino, phenylthio, alkylthio, alkylsulfinyl, phenylsulfinyl etc., (iv) alkoxycarbonylalkyl, (v) pyridyl optionally having 1 to 3 substituents such as halogen, alkoxy, and alkoxycarbonyl, (vi) phenylamino, (vii) naphthyl optionally substituted by halogen, (viii) pyrimidinyl, (ix) isoxazolyl optionally substituted by alkyl or (x) N-phthalazinylamino, or R1 and R2 together with the nitrogen atom to which they are attached from, indolinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, dihydrobenzoxazinyl or phenothiazinyl; R3 is alkyl, and X is O or S) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyceridemia, hyperphospholipidemia, hyperlipacidemia, and the like.
604124
Shima Atsushi
Shinomiya Kayoko
Shoji Yasuo
Tsuda Yoshihiko
Tsutsumi Kazuhiko
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Factory Inc.
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