Carboxamide derivatives as ion channel modulators

Details Carboxamide derivatives as ion channel modulators Carboxamide derivatives as ion channel modulators

C - Chemistry, Metallurgy

07

D

C07D 213/36 (2006.01) A61K 31/426 (2006.01) A61K 31/435 (2006.01) A61P 9/00 (2006.01) C07D 213/74 (2006.01) C07D 277/42 (2006.01)

Patent

CA 2672239

The present teachings provide compounds of Formula (I) wherein Ar, R1, R2, R3, X, p and n are defined herein. The present teachings also provide processes for producing said compounds and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

L'invention concerne des composés de Formule (I) dans laquelle Ar, R1, R2, R3, X, p et n sont tels que définis dans la description. L'invention concerne également des procédés de production de ces composés ainsi que des méthodes de traitement d'une affection ou d'un trouble pathologique, ou d'atténuation d'un symptôme associé, au moyen desdits composés. Les composés selon l'invention peuvent être utiles dans la modulation de l'activité des canaux ioniques, notamment dans le traitement de diverses affections associées à la modulation anormale d'au moins un canal calcique sensible au voltage.

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