Carboxamide derivatives as therapeutic agents

Details Carboxamide derivatives as therapeutic agents Carboxamide derivatives as therapeutic agents

C - Chemistry, Metallurgy

07

C

C07C 235/56 (2006.01) A61K 31/164 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/35 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07C 235/38 (2006.01) C07C 237/20 (2006.01) C07C 271/22 (2006.01) C07C 271/36 (2006.01) C07D 207/16 (2006.01) C07D 211/20 (2006.01) C07D 211/34 (2006.01) C07D 217/12 (2006.01) C07D 217/26 (2006.01) C07D 233/90 (2006.01) C07D 309/04 (2006.01) C07D 309/14 (2006.01) C07D 521/0

Patent

CA 2440042

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, .beta.-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

L'invention concerne certains composés, leurs méthodes de préparation, des compositions pharmaceutiques les contenant, ainsi que leur utilisation dans le traitement de maladies humaines ou animales. On utilise ces composés comme modulateurs de l'interaction entre le récepteur de produits finaux de glycation avancée (RAGE) et ses ligands, tels que des produits finaux de glycation avancée (AGE), S100/calgranulin/EN-RAGE, .beta.-amyloïde et amphotérine, et pour la gestion, le traitement, et la régulation de maladies humaines induites par RAGE, ou encore comme traitement complémentaire de ces dernières. Ces maladies ou ces états pathologiques regroupent les inflammations aiguës ou chroniques, le développement de complications tardives du diabète, telle qu'une perméabilité vasculaire accrue, la néphropathie, l'athérosclérose, et la rétinopathie, le développement de la maladie d'Alzheimer, les dysfonctionnements érectiles, l'invasion tumorale et les métastases.

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