Carboxamide heterocyclic cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/20 (2006.01) A61K 31/4353 (2006.01) A61P 25/06 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2689217

Compounds of formula I: I wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention se rapporte aux composés représentés par la formule I dans laquelle les variables A1, A2, B, m, n, J, R4, G1, G2, G3 et Y sont telles que définies dans les spécifications. Lesdits composés sont des antagonistes des récepteurs CGRP et sont utilisés dans le traitement ou la prévention de maladies associées au CGRP, par exemple la migraine. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés et des compositions dans la prévention ou le traitement des maladies associées au CGRP.

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