Carboxamide spirohydantoin cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 471/10 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2518830

The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des composés, lesquels sont des antagonistes des récepteurs du CGRP utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué, telles que des maux de tête, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques renfermant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles le CGRP est impliqué.

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