C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/395 (2006.01) A61P 25/06 (2006.01) C07D 209/96 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2579840
The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés, représentés par la formule I dans laquelle les variables A1, A2, B, J, K, m, n, R4, R5a, R5b et R5c sont telles que définies dans les spécifications, utilisés comme antagonistes des récepteurs CGRP et dans le traitement ou la prévention des maladies associées au CGRP, par exemple les maux de tête, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, et l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement des maladies associées au CGRP.
Bell Ian M.
Burgey Christopher S.
Stump Craig A.
Tucker Thomas J.
Williams Theresa M.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Carboxamide spirolactam cgrp receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carboxamide spirolactam cgrp receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carboxamide spirolactam cgrp receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2087341