Carboxamide, sulfonamide and amine compounds for metabolic...

Details Carboxamide, sulfonamide and amine compounds for metabolic... Carboxamide, sulfonamide and amine compounds for metabolic...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2707047

Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, D, E, J, T, p, q and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

L'invention concerne des composés de carboxamide, de sulfonamide et d'amine, ainsi que des compositions pharmaceutiques et des méthodes d'utilisation associées. Un mode de réalisation concerne un composé présentant la formule dans laquelle R1, R2, R4, D, E, J, T, p, q et x sont tels que définis dans la description. Certains modes de réalisation concernent un composé activant la voie AMPK et pouvant servir à traiter les troubles et affections d'origine métabolique.

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