Carboxamide, sulfonamide and amine compounds for metabolic...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/46 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 211/58 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2705947

Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

L'invention concerne des composés de carboxamide, de sulfonamide et d'amine, ainsi que des compositions pharmaceutiques et des procédés d'utilisation. Un mode de réalisation est un composé répondant à la structure dans laquelle R1, R2, R4, E, T, n et x sont comme décrit ici. Dans certains modes de réalisation, un composé révélé ici active la voie AMPK, et peut être utilisé pour traiter des troubles et affections liés au métabolisme.

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