C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/262, 260/266
C07D 401/00 (2006.01) C07D 209/48 (2006.01) C07D 209/72 (2006.01) C07D 209/76 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 407/06 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 491/08 (2006.01) C07D 491/18 (2006.01)
Patent
CA 1211436
ABSTRACT OF THE DISCLOSURE The carboximide derivatives of the formula: Image and pharmaceutically acceptable salts thereof; wherein X represents a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , a group of the formula Image , a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , a group of the formula: Image , or a group of the formula: Image ; Z represents a hydrogen atom or a group of the formula: Image wherein R represents an alkyl group having 1 to 16 carbon atoms, a group of the formula Image wherein n is an integer of from 0 to 2, and A is hydrogen atom, a lower alkyl group, a lower alkoxy group of a halogen atom, a cycloalkyl group having 3 to 10 carbon atoms, an alkenyl group having 2 to 16 carbon atoms, a cinnamyl group, a pyridyl group or an amino group of the formula Image wherein R1 and R2 are the same or different, and each repre- sent an alkyl group, hydrogen atom or a cycloalkyl group; Y represents an alkyl group of 1 to 6 carbon atoms of the for- mula Image wherein p is an integer of from 0 to 2, and X1 and X2 are the same or different, and each represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a trifluoro- methyl group, an unsubstituted pyridyl or pyrimidyl group; or a substituted pyridyl or pyrimidyl with one or more lower alkyl groups, lower alkoxy groups or halogen atoms; or a benzothiazolyl group and m represents an integer of 2 or 3 and processes for the production thereof. The derivatives and their pharmaceutically acceptable salts possess hypogly- cemic activity and are useful for treating diabetes.
403984
Akiyama Yasuhiro
Hirose Noriyasu
Kawashima Hidetoshi
Kuriyama Shizuo
Miyake Kazutoshi
Eisai Co. Ltd.
Marks & Clerk
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