C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/428, 167/47
C07F 13/00 (2006.01) A61K 51/04 (2006.01) C07F 15/00 (2006.01) G01N 33/60 (2006.01)
Patent
CA 1254901
ABSTRACT Coordination complexes comprising a radionuclide selected from the class consisting of radioactive iso- topes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: CN-X-R where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR1 and CONR2R3 where R1 can be H, a pharmaceutically accept- able cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R2, and R3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R2 and R3 can be the same or different are useful in visualizing cardiac tissue, studying lung function, studying renal excretion and have very fast liver or lung clearance; kits that can be used to form these complexes are also provided.
517219
Abrams Michael J.
Davidson Alan
Jones Alun G.
Kronauge James
Massachusetts Institute Of Technology
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
President And Fellows Of Harvard College
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