Carboxy-peptidyl derivatives as antidegenerative active agents

Details Carboxy-peptidyl derivatives as antidegenerative active agents Carboxy-peptidyl derivatives as antidegenerative active agents

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) A61K 41/00 (2006.01) C07C 255/23 (2006.01) C07C 271/22 (2006.01) C07C 275/28 (2006.01) C07C 279/14 (2006.01) C07C 317/48 (2006.01) C07D 207/16 (2006.01) C07D 209/34 (2006.01) C07D 209/44 (2006.01) C07D 209/48 (2006.01) C07D 213/75 (2006.01) C07D 235/16 (2006.01) C07D 263/56 (2006.01) C07D 277/64 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2149640

2149640 9412169 PCTABS00032 Novel carboxy-peptidyl compounds of formula (I) are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. The matrix metalloendoproteinases are a family of zinc-containing proteinases including but not limited to stromelysin, collagenase, and gelatinase, that are capable of degrading the major components of articular cartilage and basement membranes. The inhibitors claimed herein may also be useful in preventing the pathological sequelae following a traumatic injury that could lead to a permanent disability. These compounds may also have utility as a means for birth control by preventing ovulation or implantation.

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