C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/64 (2006.01) A61K 31/445 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2329075
The present invention relates to novel carboxy substituted acyclic carboxamide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
La présente invention concerne de nouveaux dérivés carboxamides acycliques à substitution carboxy de formule (1), ainsi que les stéréoisomères et les sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également l'utilisation de ces nouveaux dérivés comme antagonistes du récepteur de la tachykinine. Ces antagonistes sont utiles pour traiter les maladies et les états induits par la tachykinine, notamment l'asthme, la toux, et la bronchite.
Burkholder Timothy P.
Kudlacz Elizabeth M.
Maynard George D.
Aventis Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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