C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/325.1, 260/3
C07D 207/16 (2006.01) C07D 207/22 (2006.01) C07D 207/24 (2006.01) C07D 207/46 (2006.01) C07D 491/10 (2006.01) C07D 491/107 (2006.01) C07D 495/10 (2006.01) C07F 9/54 (2006.01)
Patent
CA 1168245
ABSTRACT Compounds, compositions and method of alleviat- ing hypertension using a compound of the formula Image wherein R is hydrogen or lower alkyl; R1 is hydrogen, lower alkyl or phenyl-lower alkyl; R2 is hydrogen, lower alkyl, phenyl lower alkyl or halo substituted lower alkyl; R3 is hydroxy, -NHOH or lower alkoxy; Pr-COOR is a substituted proline of the struc- tures Image or Image R4 is halogen, keto, azido, cycloalkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, Image , or Y-R6; R5 is hydrogen or lower alkyl; Y is oxygen or sulfur; R6 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, 1- or 2-naphthyl, substituted 1- or 2- naphthyl, biphenyl, or substituted biphenyl; R7 is halogen or -Y-R8; R8 is lower alkyl, phenyl, phenyl-lower alkyl substituted phenyl-lower alkyl, biphenyl, napthyl, or the R6 groups join to complete an unsubstituted 5- or 6- membered ring or such ring wherein one or more carbon atoms are substituted by a lower alkyl or di(lower alkyl) group; R9 is keto, phenyl, 2- or 4-hydroxyphenyl; n is 0 or 1; and salts thereof.
386319
Condon Michael E.
Ondetti Miguel A.
Osler Hoskin & Harcourt Llp
Squibb (e.r.) & Sons Inc.
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