C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.06
C07K 5/06 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1257749
ABSTRACT OF THE DISCLOSURE Compounds of the formula Image wherein A and A' are independently hydroxy, alkoxy, aryloxy, or hydroxyamino; R1, R2, R4 and R5 are independently hydrogen, alkyl, aryl, aralkyl, fused cycloalkylaryl, fused arylcyclo- alkyl, aryloxyalkyl, or arylalkyloxyalkyl; R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused cycloalkylaryl, fused arylcycloalkyl, fused cycloalkylarylalkyl, fused arylcycloalkylalkyl, aralkyl, cycloalkyl, or heterocyclic; and R6 is hydrogen, alkyl, alkenyl, alkynyl, acyl, cycloalkyl, cycloalkylalkyl, polycycloalkyl, polycyclo- alkylalkyl, aryl, aralkyl, polycyclic aryl, fused cyclo- alkylaryl, fused arylcycloalkyl, fused arylcycloalkyl- alkyl, or fused cycloalkylarylalkyl; and wherein the alkyl and alkyl moieties in the sub- stituents contain 1 to 9 carbon atoms; the lower alkyl contains 1 to 6 carbom atoms; the alkenyl and alkynyl and the groups and moieties of these substituents contain 2 to 9 carbon atoms; the heterocyclic, aryl and the aryl moieties contain 6 to 10 carbon atoms; the cycloalkyl and the cycloalkyl groups and moieties contain 3 to 9 carbon atoms; the polycycloalkyl con- tains 6 to 20 carbon atoms; and the acyl is alkynoyl, aroyl, aralkanyl, sulfonyl, sulfamoyl, and carbamoyl wherein the alkyl and aryl moieties are as above defined. These compounds are useful for treating hypertension.
445192
Huang Fu-Chih
Jones Howard
Lin Clara J.
Loev Bernard
Mcfadden Fincham
Usv Pharmaceutical Corporation
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