A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/255 (2006.01) A61K 31/194 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2413906
The invention is a pharmaceutical composition comprising a carboxyalkylether which lowers triglycerides and LDL and elevates HDL, and an ACAT inhibitor which improves dyslipidemias in mammals, said composition being useful for treating dyslipidemia and ischemic syndromes, and for preventing or delaying the onset of heart attacks. The carboxyalkylethers have the formula (I) wherein Y1 and Y2 include COOH, R1, R2, R3, and R4 can be alkyl, and n and m are integers from 2 to 9; and the ACAT inhibitors have the formula (IV) where R is hydrogen, X is O, R1 and R2 are substituted phenyl, and Y is alkylene.
L'invention porte sur une préparation pharmaceutique comportant: un carboxyalkyléther qui abaisse le niveau des triglycérides et du LDL et augmente celui du HDL; et un inhibiteur de l'ACAT améliorant les dyslipidémies chez les mammifères, ladite préparation s'avère donc utile pour traiter les dyslipidémies et les syndromes ischémiques, et prévenir ou retarder l'apparition des crises cardiaques. Lesdits carboxyalkyléthers présentent la formule (I) dans laquelle: Y¿1? et Y¿2? comportent COOH, R¿1?, R¿2?, R¿3?, et R¿4? peuvent être alkyle, et n et m sont des entiers de 2 à 9, tandis que les inhibiteurs de l'ACAT présentent la formule (II) dans laquelle: R est H, X est O, R¿1? et R¿2? sont phényle substitué, et Y est alkylène.
Auerbach Bruce Jeffrey
Zobel Donna Lee
Sim & Mcburney
Warner-Lambert Company
LandOfFree
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