Carboxyl- or hydroxylsubstituted benzimidazole derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 235/18 (2006.01) A61K 31/41 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61P 3/00 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2708372

This invention relates to novel carboxyl- or hydroxylsubstituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.

L'invention porte sur de nouveaux dérivés de benzimidazole substitués par carboxyle ou hydroxyle représentés par la formule (I) dans laquelle R1 à R6 sont tels que définis dans la description et dans les revendications, ainsi que sur des sels et esters physiologiquement acceptables de ceux-ci. Ces composés se lient à FXR et peuvent être utilisés en tant que médicaments.

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