C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/94 (2006.01) A61K 31/235 (2006.01) A61K 31/33 (2006.01) C07C 65/24 (2006.01) C07C 69/92 (2006.01) C07C 209/48 (2006.01) C07C 217/22 (2006.01) C07C 233/69 (2006.01) C07C 233/92 (2006.01) C07C 235/46 (2006.01) C07C 235/60 (2006.01) C07C 311/17 (2006.01) C07C 311/48 (2006.01) C07C 317/18 (2006.01) C07C 317/22 (2006.01) C07C 323/03 (2006.01) C07C 323/20 (2006.01) C07D 209/48 (2006.01) C07D 211/70 (2006.01) C07D 275/06 (2006.01) C07D 295/092 (2006.01) C07D 295/155 (2006.01) C07D 317/64 (2006.01)
Patent
CA 2133115
- 113 - ABSTRACT OF DISCLOSURE Novel carboxylate derivatives exhibiting phospholipase A2 inhibitory activity are disclosed. Specifically, the following compounds of the formula and pharmaceutically acceptable salts thereof are disclosed: Image (I) wherein A is hydroxy, amino, or lower alkylamino; R1 to R12 are independently hydrogen, methyl, methoxy, or hydroxy, provided that all of R1 to R12 are not hydrogen; G1 is a single bond, or a group of -(CH2)xO(CH2)y- wherein x and y are independently 0-5; G2 is a single bond, oxygen, sulfur, carbonyl, etc.; G3 is alkyl, aryl, or a group of the formula: Image wherein R13 and R14 are independently hydrogen, alkyl, aryl, etc.; or R13 and R14 may be taken together with the adjacent nitrogen atom to form a heterocyclic group or a group of the formula: Image wherein Z is a carbon atom or a nitrogen atom, J, K ,and L are independently hydrogen or aryl, etc.; p and q are independently 0, 1, or 2; and n is an integer of 1 to 8.
Hori Yozo
Kato Toshiyuki
Ohtani Mitsuaki
Kirby Eades Gale Baker
Shionogi & Co. Ltd.
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