Carboxylic acid compound and a pharmaceutical agent...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 265/36 (2006.01) A61K 31/538 (2006.01) A61P 1/04 (2006.01) A61P 7/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 25/06 (2006.01) A61P 25/20 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 209/12 (2006.01) C07D 307/80 (2006.01) C07D 319/20 (2006.01) C07D 327/06 (2006.01)

Patent

CA 2479352

Carboxylic acid compounds represented by the following general formula (I) (wherein each symbol is as defined in the description) and drugs containing these compounds: (I) Because of binding to DP receptor and antagonizing the same, the compounds represented by the general formula (I) are useful in preventing and/or treating allergic diseases (allergic nephritis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc.), systemic mast cell disease, systemic mast cell activation failure, anaphylactic shock, respiratory tract contraction, urticaria, eczema, diseases associated with itch (atopic dermatitis, urticaria, etc.), diseases (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.) secondarily caused by behaviors associating itch (scratching, beating, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion injury, cerebrovascular disorder, rheumatoid arthritis, pleuritis, ulcerative colitis and so on.

L'invention concerne des composés d'acide carboxylique représentés par la formule générale suivante (I) (dans laquelle chaque symbole est tel que défini dans la description), ainsi que des médicaments renfermant ces composés : (I). Les composés représentés par la formule générale (I) sont utiles, en raison de leur liaison au récepteur DP et de leur antagonisation de celui-ci, dans la prévention et/ou le traitement des maladies allergiques (néphrite allergique, conjonctivite allergique, eczéma constitutionnel, asthme bronchique, allergie alimentaire, etc.), de la mastocytose diffuse, de la défaillance de l'activation de la mastocytose diffuse, du choc anaphylactique, de la contraction des voies respiratoires, de l'urticaire, de l'eczéma, des maladies associées à des démangeaisons (eczéma constitutionnel, urticaire, etc.), des maladies (cataracte, décollement de la rétine, inflammation, infection, trouble du sommeil, etc.) occasionnées de manière secondaire par des comportements associés aux démangeaisons (égratignure, raclée, etc.), d'inflammation, de la broncho-pneumopathie chronique obstructive, des lésions occasionnées par la reperfusion ischémique, d'un trouble cérébro-vasculaire, de la polyarthrite rhumatoïde, de la pleurésie, de la rectocolite hémorragique, etc.

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