Carboxylic acid compounds and medicinal compositions...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 265/36 (2006.01) A61K 31/343 (2006.01) A61K 31/357 (2006.01) A61K 31/538 (2006.01) A61P 37/08 (2006.01) C07D 307/80 (2006.01) C07D 317/46 (2006.01) C07D 319/20 (2006.01)

Patent

CA 2539070

A compound represented by formula (I) (see formula I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.

L'invention concerne des composés de formule générale (I), la signification de chaque symbole de ladite formule étant indiquée dans la description, ainsi que des sels, des solvates et des promédicaments desdits composés qui se lient à des récepteurs DP et qui sont antagonistes de ceux-ci. Lesdits composés sont utiles dans la prévention et/ou le traitement de maladies de type maladies allergiques (néphrite allergique, conjonctivite allergique, dermatite atopique, asthme, allergie alimentaire, etc.), mastocytoses systémiques, troubles d'activation des mastocytes systémiques, choc anaphylactique, contraction des voies respiratoires, urticaire, eczéma, maladies accompagnées de prurits (dermatite atopique, urticaire, etc.), maladies secondaires (cataracte, décollement de la rétine, inflammation, infection, troubles du sommeil, etc.), provoquées par des comportements associant les prurits (démangeaisons, coups, etc.), inflammation, bronchopneumopathie chronique obstructive, lésions de reperfusion ischémique, troubles vasculaires cérébraux, polyarthrite rhumatoïde, pleurésie, rectocolite hémorragique, etc. En raison de leur capacité de liaison spécifique aux récepteurs DP et de faible liaison à d'autres récepteurs de prostaglandine, lesdits composés permettent d'obtenir des médicaments présentant des effets secondaires réduits.

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