C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/63 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) B01F 17/00 (2006.01) C07C 59/135 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2474626
The invention relates to compounds of formula (I) or a salt or solvate thereof, wherein: x represents 0 or 1; y represents 0 or 1; R1~ and R2~ independently represent -C~1-9 alkyleneC~1-6 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms and wherein said R1~ and/or R2~ moiety is optionally interrupted by an ether link, processes for their preparation, use of said compounds in the preparation of pharmaceutical aerosol formulations and said formulations.
L'invention concerne des composés de formule (I) ou un sel ou un solvate correspondant. Dans cette formule, x représente 0 ou 1, y représente 0 ou 1, R1 et R2 représentent indépendamment -C1-9 alkylène C1-6 fluoroalkyle, ledit groupe caractéristique du fluoroalkyle contenant au moins un atome de fluor et pas plus de 3 atomes de perfluorocarbone consécutifs, et R1 et/ou R2 sont facultativement interrompus par une liaison d'éther. Cette invention a également trait à des procédés de conception desdits composés, à leur utilisation dans l'élaboration de préparations pharmaceutiques en aérosol et à ces préparations.
Looker Brian Edgar
Lunniss Christopher James
Redgrave Alison
Glaxo Group Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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