C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 25/00 (2006.01) A61P 43/00 (2006.01) C07D 263/48 (2006.01) C07D 277/24 (2006.0
Patent
CA 2465861
Compounds represented by the following general formula (I) or salts thereof: (I) wherein each symbol is as defined in the description; and peroxisome proliferator activated receptor regulators containing the same as the active ingredient. Because of having an activity of regulating peroxisome proliferator activated receptors, the compounds represented by the general formula (I) are useful as hypoglycemics, hypolipidemics, preventives and/or remedies for metabolic errors such as diabetes, obesity, syndrome X, hypercholesterolemia and hyperlipoproteinemia, hyperlipemia, arteriosclerosis, hypertension, circulatory diseases, hyperphagia, ischemic heart diseases, etc., HDL cholesterol-elevating agents, LDL cholesterol and/or VLDL cholesterol-lowering agents and risk factor-lowering agents for diabetes and syndrome X.
L'invention concerne des composés de formule générale (I) ou des sels de ceux-ci. Chaque symbole est défini dans la description et des régulateurs de récepteurs activés de proliférateurs de peroxisome contiennent ces composés en tant que principe actif. En raison d'une activité de régulation des récepteurs activés de proliférateurs de peroxisome, les composés de formule (I) sont utiles en tant que médicaments hypoglycémiques, hypolipémiants, médicaments préventifs et/ou curatifs d'erreurs métaboliques telles que les diabètes, l'obésité, le syndrome X, l'hypercholestérolémie et l'hyperlipoprotéinémie, l'hyperlipémie, l'artériosclérose, l'hypertension, les maladies circulatoires, l'hyperphagie, les maladies cardiaques ischémiques, etc., et qu'agents permettant d'élever le taux de cholestérol HDL, agents permettant d'abaisser le taux de cholestérol LDL et/ou de cholestérol VLDL, et agents permettant d'abaisser le facteur de risque pour des diabètes et le syndrome X.
Nakayama Yoshisuke
Tajima Hisao
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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