Carboxylic acid derivatives

Details Carboxylic acid derivatives Carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

260/294, 260/246

C07D 413/12 (2006.01) C07D 211/78 (2006.01)

Patent

CA 1144545

ABSTRACT The invention concerns novel 1-benzyl-1,2,5,6- tetrahydropyridine-3-carboxylic acid derivatives of the formula:- Image I wherein R1 is hydroxy, amino, (1-4C)alkylamino, di- [(1-4C)alkyl]amino, benzyloxy optionally substituted by halogeno, or (1-6C)alkoxy optionally substituted by (1-4C)alkoxy, morpholino or di-{(1-4C)alkyl]amino; and benzene ring A bears one or two substituents selected from halogeno, (1-4C)alkyl, cyano, carboxamido, trifluoromethyl and hydroxy; and their pharmaceutically acceptable salts; together with pharmaceutical compositions thereof; and analogy processes for their manufacture. The compounds of formula I are inhibitors of the aggregation of blood platelets and may be or application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. A repres- entative compound of the invention is 1-(2-chloro- benzyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid.

346021

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