Carboxylic acid derivatives

Details Carboxylic acid derivatives Carboxylic acid derivatives

C - Chemistry, Metallurgy

07

F

167/126, 260/314

C07F 9/94 (2006.01) A61K 31/29 (2006.01) A61K 31/555 (2006.01) C07D 211/20 (2006.01) C07D 233/54 (2006.01) C07D 249/14 (2006.01) C07D 277/28 (2006.01) C07D 277/42 (2006.01) C07D 295/096 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2001436

The invention relates to salts formed between basic H2-receptor antagonists and a complex of bismuth with a carboxylic acid, and solvates of such salts, excluding salts in which the basic H2-receptor antagonist is ranitidine. Examples of suitable carboxylic acids are citric acid and tartaric acid. Examples of basic H2-receptor antagonists are cimetidine, sufotidine famotidine and nizatidine. The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with the basic H2-receptor antagonist together with antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties.

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