C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/246, 260/476
C07C 59/70 (2006.01) A61K 31/095 (2006.01) A61K 31/16 (2006.01) A61K 31/185 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) C07C 51/06 (2006.01) C07C 51/09 (2006.01) C07C 51/367 (2006.01) C07C 59/00 (2006.01) C07C 59/125 (2006.01) C07C 59/13 (2006.01) C07C 59/58 (2006.01) C07C 59/64 (2006.01) C07C 59/68 (2006.01) C07C 69/708 (2006.01) C07C 69/712 (2006.01) C07C 69/734 (2006.01) C07C 69/736 (2006.01) C07C 233/00 (2006.01) C07C 233/01 (2006.01) C07C 309/00 (2006.01) C07C 313/00 (2006.01) C07C 317/00 (200
Patent
CA 1316933
ABSTRACT New carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them The present invention provides carboxylic acid derivatives of the general formula:- Image (I), wherein 1 is an alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylamino, cycloalkyl or cycloalkoxy radical or an optionally substituted aryl, aryloxy1 arylthio, arylsulphinyl, arylsulphonyl or arylamino radical, R2 is an optionally substituted aryl radical or, when B is an alkylene radical, is also a hydrogen atom, A a straight-chained or branched, saturated or unsaturated alkylene radical containing 3 to 10 carbon atoms which is optionally interrupted by a heteroatom and has a chain length of at least 3 atoms, with the proviso that a heteroatom is not to be attached to an unsaturated aliphatic carbon atom, Y is an S(O)n group or an oxygen atom, n is 0, 1 or 2 and B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene radical containing 1 to 5 carbon atoms, as well as the physiologically acceptable salts, esters and amides thereof; the derivatives may be used in the treatment of diabetes and prediabetes and especially for the treatment of maturity onset diabetes and in the treatment of fat metabolism diseases and non-diabetic disease states in which an insulin resistance is present.
555671
Kuehnle Hans-Frieder
Witte Ernst-Christian
Wolff Hans P.
Boehringer Mannheim G.m.b.h.
Kuehnle Hans-Frieder
Swabey Ogilvy Renault
Witte Ernst-Christian
Wolff Hans P.
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