C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/43 (2006.01) A61K 31/19 (2006.01) A61K 31/196 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/277 (2006.01) A61K 31/381 (2006.01) A61K 31/4045 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61P 1/04 (2006.01) A61P 1/10 (2006.01) A61P 1/12 (2006.01) A61P 1/18 (2006.01) A61P 3/12 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 13/00 (2006.01) A61P 13/02 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 1
Patent
CA 2420042
Carboxylic acid derivatives represented by the following general formula (I) and nontoxic salts thereof: (I) wherein R1 represents COOH, COOR6, etc.; A represents alkylene, etc.; R2 represents alkyl, alkenyl, alkynyl, etc.; B represents a carbon ring or a heterocycle; R4 represents alkyl, cycloalkyl, etc.; and R5 represents a carbon ring or a heterocycle. The compounds represented by the general formula (I) bind to PGE2 receptors, in particular, subtypes EP3 and/or EP4 and exert an antagonism, which makes them useful in preventing and/or treating diseases such as pain, allergy, Alzheimer and cancer.
L'invention concerne des dérivés d'acide carboxylique représentés par la formule générale (1), et des sels non toxiques de ceux-ci. Dans la formule, R?1¿ représente COOH, COOR?6¿, etc. ; A représente alkylène, etc. ; R?2¿ représente alkyle, alcényle, alcynyle, etc. ; B représente un noyau carbone ou un hétérocycle ; R?4¿ représente alkyle, cycloalkyle, etc. ; et R?5¿ représente un noyau carbone ou un hétérocycle. Les composés représentés par la formule générale (1) se lient aux récepteurs PGE¿2?, notamment aux sous-types EP¿3? et/ou EP¿4? et ont un effet antagoniste qui les rend utiles dans la prévention et/ou le traitement d'affections telles que la douleur, les allergies, la maladie d'Alzheimer et le cancer.
Asada Masaki
Kobayashi Kaoru
Narita Masami
Ogawa Mikio
Tani Kousuke
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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