Carboxylic acid derivatives that inhibit the binding of...

Details Carboxylic acid derivatives that inhibit the binding of... Carboxylic acid derivatives that inhibit the binding of...

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/435 (2006.01) A61K 31/4412 (2006.01) A61K 31/4427 (2006.01) A61K 31/4704 (2006.01) A61K 31/50 (2006.01) A61K 31/55 (2006.01) C07D 215/38 (2006.01) C07D 221/18 (2006.01) C07D 237/22 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2373360

A method for the inhibition of the binding of .alpha.4.beta.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha.4.beta.1 is involved.

L'invention concerne un procédé destiné à inhiber la liaison entre l'intégrine .alpha.¿4?.beta.¿1? et ses récepteurs, tels que la molécule-1 d'adhésion cellulaire vasculaire (VCAM-1) et la fibronectine. L'invention concerne également des composés qui inhibent cette liaison, des compositions pharmaceutiquement actives contenant ces composés, et l'utilisation de ces composés tels qu'ils sont décrits ci-dessus ou dans des formulations destinées au contrôle ou à la prévention d'états pathologiques dans lesquels est impliquée l'intégrine .alpha.¿4?.beta.¿1?.

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