C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) C07D 239/94 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/10 (2006.01) C07D 519/00 (2006.01) C07F 9/09 (2006.01) C07F 9/38 (2006.01) C07F 9/6512 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2509239
Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
L'invention concerne des analogues de la quinazolin-4-ylamine substitués par acide. Lesdits composés sont des ligands qui peuvent servir à moduler l'activité de récepteurs spécifiques in vivo ou in vitro, et sont particulièrement utiles au traitement de troubles associés à l'activation pathologique de récepteurs chez les humains, les animaux domestiques et le bétail. L'invention a également trait à des compositions pharmaceutiques et à des procédés d'utilisation de ces dernières, qui permettent de traiter de tels troubles, ainsi qu'à des procédés d'utilisation de tels ligands pour des études de localisation de récepteurs.
Bakthavatchalam Rajagopal
Blum Charles A.
Brielmann Harry
Caldwell Timothy M.
de Lombaert Stephane
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Neurogen Corporation
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