Carboxylic acids and carboxylic acid isosteres of...

Details Carboxylic acids and carboxylic acid isosteres of... Carboxylic acids and carboxylic acid isosteres of...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/4025 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/55 (2006.01) C07D 207/12 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2333963

This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres represented by formula (I), their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth. In said formula, n is 1-3; X is either O or S; R1 is selected from the group consisting of C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, aryl, heteroaryl, carboncycle, or heterocycle; D is a bond, or a C1-C10 straight or branched chain alkyl, C2-C10 alkenyl or C2-C10 alkynyl; R is as defined in the application.

L'invention concerne de nouveaux acides carboxyliques et isostères d'acides carboxyliques représentés par la formule (I), ainsi que leur élaboration, et leur utilisation pour traiter des troubles neurologiques, y compris les nerfs physiquement endommagés et les maladies neurodégénératives, et aussi pour traiter l'alopécie et favoriser la pousse des cheveux. Dans ladite formule, n a une valeur comprise entre 1 et 3; X est O ou S; R1 est choisi dans la série alkyle C1-9 à chaîne droite ou ramifiée, alcényle C2-9 à chaîne droite ou ramifiée, aryle, hétéroaryle, carbonyle ou hétérocycle; D est une liaison, ou bien alkyle C1-10 à chaîne droite ou ramifiée, alcényle C2-10 ou alkynyle C2-10; est tel que défini dans l'invention.

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