Carcinoembryonic antigen derivatives

Details Carcinoembryonic antigen derivatives Carcinoembryonic antigen derivatives

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2116640

Abstract The present invention provides recombinant CEA glycoprotein derivatives and to methods for their production. These recombinant CEA glycoprotein derivatives are characterized in that they are free from cross-reactive CEA- like antigens, antigenically indistingiushable from the soluble form of CEA shed from tumor cells and devoid of ethanolamine. Said derivatives preferably have the amino acid sequence [SEQ ID NO: 1]. The said CEA glycoprotein derivatives may be used as reagents in an immunoassay for the diagnosis of neoplastic diseases. The invention also relates to a DNA encoding a said recombinant CEA glycoprotein derivative such as the DNA having the nucleotide sequence [SEQ ID NO: 2] or a functional equivalent sequence thereof. The present invention also relates to recombinant vectors comprising a said DNA, which recombinant vector is capable of directing the expression of the said DNA in a compatible host cell and to transformed host cells containing such a recombinant vector. The recombinant CEA glycoprotein derivative of the present invention, preferably integrated in a test-kit may be used for determining the presence of tumor cells in a sample of body fluid.

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