C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61P 35/00 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 31/415 (2006.01)
Patent
CA 2761946
The present invention provides methods and kits a) for predicting colorectal cancer patient survival, as well as the survival of patients harboring other invasive cancers where cellular proliferation and carcinogenesis is linked, in part, to high levels of ODC activity and increased cellular polyamine contents, and b) for selecting the corresponding treatment options for such patients based on the allelic nucleotide sequence or SNP at position +316 of the ODC1 promoter gene as well as cancer treatment methods, in each case, which include the determination of the ODC1 promoter +316 position genotype, as a means to guide treatment selection.
La présente invention concerne des méthodes et des nécessaires permettant a) de prédire les chances de survie d'un patient souffrant d'un cancer colorectal, ainsi que de patients porteurs d'autres cancers invasifs dans lesquels la prolifération cellulaire et la carcinogenèse sont liées, pour partie, à des niveaux élevés d'activité ODC et à des concentrations cellulaires accrues de polyamine, et b) de choisir les options thérapeutiques adaptées auxdits patients sur la base de la séquence nucléotidique allélique ou du SNP en position +316 du gène promoteur de l'ODC1, ainsi que des méthodes de traitement anticancéreux qui impliquent dans chaque cas, la détermination du génotype de la position +316 du promoteur de l'ODC1, qui va servir de guide pour le choix du traitement.
Anton-Culver Hoda
Gerner Eugene
Mclaren Christine
Meyskens Frank
Thompson Patricia A.
Arizona Board Of Regents On Behalf Of The University Of Arizona
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Regents Of The University Of California A. California Corporation
LandOfFree
Carcinoma diagnosis and treatments, based on odc1 genotype does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carcinoma diagnosis and treatments, based on odc1 genotype, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carcinoma diagnosis and treatments, based on odc1 genotype will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2074086