Carcinoma-marking monoclonal antibodies elicited with...

C - Chemistry – Metallurgy – 07 – K

Patent

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167/10, 195/1.10

C07K 16/30 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01)

Patent

CA 1340014

A novel carcinoma binding monoclonal antibody is provided herein. Such monoclonal antibody specifically binds at least some human lung, colon and breast carcinomas and: (a) specifically binds to TF-beta-HSA, but not to Tn-HSA, and further specifically binds the epitope specifically bound by monoclonal antibody 1155H.7; or (b) specifically binds the epitope specifically bound by monoclonal antibody 170H.82. Radioimmunoimaging agents are also provided in which such antibodies are tagged with radiometals or radiohalogens.

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