Carcinoma orosomucoid-related antigen, a monoclonal antibody...

Details Carcinoma orosomucoid-related antigen, a monoclonal antibody... Carcinoma orosomucoid-related antigen, a monoclonal antibody...

C - Chemistry, Metallurgy

12

N

167/37, 195/1.10

C12N 5/18 (2006.01) A61K 39/00 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339801

Disclosed is a glycoprotein, CORA, which has a binding affinity for carcinoembryonic antigen (CEA). This glycoprotein is a marker for carcinoma, and can be characterized by having a molecular weight of about 46,000 - 50,000 daltons, an isoelectric point of about 3.0 - 3.5, a carbohydrate content of about 25 -35% by weight, reactivity with antisera raised thereto, and substantially no reactivity with antisera raised to nonspecific cross-reacting antigen (NCA) or to CEA. Also disclosed are a hybridoma which produces a monoclonal antibody to CORA, the monoclonal antibody to CORA, and a device, kit, and method for detecting and monitoring carcinoma.

592762

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