Cardiac-derived stem cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/0775 (2010.01) C12N 5/077 (2010.01) A61K 35/34 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2324350

The invention provides cardiac-derived pluripotent stem cells, which on proliferation and differentiation can produce a variety of cell types including cardiocytes, fibroblasts, smooth muscle cells, skeletal muscle cells, keratinocytes, osteoblasts and chondrocytes. The cells can be used in methods of treating patients suffering from necrotic heart tissue. The stem cells proliferate and differentiate to produce cardiocytes replacing the necrotic tissue. The cells can also be used to screen compounds for activity in promoting proliferation and/or differentiation of cardiac-derived stem cells.

L'invention concerne des cellules souches hématopoïétiques d'origine cardiaque, qui une fois soumises à la prolifération et à la différentiation, peuvent produire divers types de cellules, notamment des cardiocytes, des fibroblastes, des cellules musculaires lisses, des cellules musculaires squelettiques, des kératinocytes, des ostéoblastes, et des chondrocytes. Les cellules de cette invention peuvent être utilisées dans différentes méthodes permettant de traiter des patients souffrant d'un tissu cardiaque nécrotique, ces cellules souches subissant la prolifération et la différentiation de manière à produire des cardiocytes destinés à remplacer ledit tissu nécrotique. Ces cellules peuvent également être utilisées pour détecter des composés qui présentent une activité favorisant la prolifération et/ou la différentiation de cellules souches d'origine cardiaque.

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