Cardiac pressure overload associated genes

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C12M 1/34 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2580191

The present invention identifies genes whose gene products are differentially expressed pressure overload of the heart. The invention provides methods for diagnosing or assessing an individual's susceptibility to heart failure from many etiologies, as well as the presence and severity of hypertrophy, chamber enlargement, or systolic heat failure. Also provided are therapeutic methods for treating a heart patient or methods for prophylactically treating an individual susceptible to heart failure. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered a heart attack or are at risk of heart failure.

La présente invention identifie des gènes dont les produits géniques exprimés de façon différentielle correspondent à la surcharge de pression cardiaque. L'invention concerne des procédés pour diagnostiquer ou pour évaluer la vulnérabilité d'un individu à une insuffisance cardiaque d'étiologies différentes ainsi que la présence et la gravité d'une hypertrophie, d'un élargissement de chambre ou d'une insuffisance cardiaque systolique. L'invention concerne également des procédés thérapeutiques destinés à traiter un patient cardiaque ou des procédés d'un traitement prophylactique d'un individu vulnérable à une insuffisance cardiaque. En outre, l'invention concerne des précédés de criblage destinés à identifier des agents qui peuvent être administrés pour traiter des individus qui ont subi une crise cardiaque ou courent le risque d'une insuffisance cardiaque.

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