Cardiolipin compositions their methods of preparation and use

Details Cardiolipin compositions their methods of preparation and use Cardiolipin compositions their methods of preparation and use

C - Chemistry, Metallurgy

07

F

C07F 9/10 (2006.01) A61K 9/127 (2006.01) A61K 31/522 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01)

Patent

CA 2486967

The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

L'invention porte sur de nouveaux procédés synthétiques de préparation de la cardiolipine qui utilisent différents acides gras et/ou chaînes alkyle de longueur variable, avec ou sans insaturation. Les schémas réactionnels peuvent être utilisés pour générer de nouvelles formes de cardiolipine, y compris des variants de cardiolipine. La cardiolipine, préparée selon les procédés de cette invention, peut être incorporée, sans inconvénient, à des liposomes et autres formulations lipidiques pouvant également comprendre des agents actifs tels que des médicaments hydrophobes ou hydrophiles. Ces formulations peuvent être utilisées dans le traitement de maladies ou dans des essais diagnostiques et/ou analytiques. Les liposomes peuvent également comprendre des ligands, par exemple, pour leur ciblage sur un type de cellule ou un tissu spécifique.

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