Cardiomyocytes with enhanced proliferative potential

Details Cardiomyocytes with enhanced proliferative potential Cardiomyocytes with enhanced proliferative potential

C - Chemistry, Metallurgy

12

N

C12N 1/00 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2377270

Described are methods in vitro and in vivo which involve the use of increased cyclin D2 activity to activate the cell cycle of cardiomyocytes as a baseline measure and/or in response to stimuli. Also described are vectors useful for these purposes, and cardiomyocyte cells exhibiting an activated cell cycle. Transgenic cyclin D2 animal models are also described.

La présente invention concerne des procédures in vivo et in vitro impliquant une activité cycline D2 accrue pour activer le cycle cellulaire des cardiomyocytes comme ligne de base et/ou en réaction à des stimuli. L'invention concerne également des vecteurs convenant à ces fins, et des cellules, en l'occurrence des cardiomyocytes, faisant preuve d'un cycle cellulaire activé. L'invention concerne enfin des modèles animaux transgéniques de cycline D2.

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