Cardioprotective delta opioid receptor agonists and methods...

Details Cardioprotective delta opioid receptor agonists and methods... Cardioprotective delta opioid receptor agonists and methods...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2552261

The present invention relates to compositions and methods of treatment for cardioprotection through the use of non-peptidic delta opioid receptor agonist compound(s) that mediate cardioprotective effects of ischemic preconditioning. The compounds are used to reduce injury associated with ischemia and reperfusion of cardiac tissue. Further, the compounds may be used in solutions preserving the viability of an isolated organ.

La présente invention concerne des compositions et des méthodes thérapeutiques permettant la protection cardiaque grâce à l'utilisation d'un ou de plusieurs composés agonistes non peptidiques du récepteur opioïde .DELTA. procurant des effets cardioprotecteurs du préconditionnement ischémique. Les composés susmentionnés sont utilisés pour réduire une lésion associée à l'ischémie et à la reperfusion du tissu cardiaque. En outre, ces composés peuvent être utilisés dans des solutions préservant la viabilité d'un organe isolé.

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