C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/58 (2006.01) A61K 31/44 (2006.01) A61K 31/675 (2006.01) C07D 213/65 (2006.01) C07D 213/66 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2401655
The present invention provides for pyrodoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonates analogues, such as, for example, ((2-methyl-3-hydroxy-4- hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.
La présente invention concerne des analogues de phosphonates de pyridoxine tels que, par exemple, (2-méthyl-3-hydroxy-4-hydroxyméthyl-5-pyridyl)alkylphosphonates, et ((2-méthyl-3-hydroxy-4-hydroxyméthyl-5-pyridyl)azaalkylphosphonates) ainsi que des analogues de malonates de pyridoxine, tels que, par exemple, ((2-méthyl-3-hydroxy-4-hydroxyméthyl-5-pyridylméthyl)malonates). L'invention concerne également des compositions pharmaceutiques, et des procédés de traitement des maladies cardiovasculaires et associées, et du diabète sucré et maladies associées.
Medicure International Inc.
Ridout & Maybee Llp
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