Cardioprotective tocopherol analogs

Details Cardioprotective tocopherol analogs Cardioprotective tocopherol analogs

C - Chemistry, Metallurgy

07

D

C07D 311/70 (2006.01) A61K 31/355 (2006.01) C07D 311/72 (2006.01)

Patent

CA 2002649

This invention relates to alkylamino alkylene derivatives of certain 2H-1-benzopyrans, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cellular protective properties and to their end-use application as therapeutic agents. More specifically this invention relates to alkylamino alkylene derivatives of the formula Image the (R) and (S) enantiomers and racemic mixtures thereof, and the pharmaceutically acceptable salts thereof wherein Q is N~R1R2R3.X~, X is a halide or OS(O)2R4, with R4 being H, C1-6 alkyl, aryl or aralkyl, R1, R2 and R3 each individually are a C1-6 lower alkyl, R5 is H or C1-6 alkyl, R6 is H or -C(O)R, R being H or C1-9 alkyl, R7 is H or C1-6 alkyl, R8 is H or C1-6 alkyl and n is an integer of 1 to 6.

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